A Biochemical Society Event
Membrane proteins play a vital role in intracellular communication and the control of molecular movement across the membrane, making them key therapeutic targets for a wide range of human diseases. Their location within the membrane, tightly packed with so many different proteins and lipids has, until now, made them extremely challenging to study. To gain a meaningful insight into the function of a single protein, it needs to be separated from the complexity of the membrane.
Conventionally, this is achieved using detergents, which often cause loss of function by stripping away the native lipid environment or loss of lateral pressure. The application of styrene-maleic acid (SMA) co-polymers to extract small discs of membrane, termed SMA lipid particles (SMALPs), allowing membrane proteins to be purified and studied whilst maintaining their lipid environment has changed the established research landscape. This ‘SMALP' methodology allows techniques that were previously not possible to be utilised to study membrane protein structure and function.
This meeting will explore the latest developments within the field, including novel polymers, techniques and targets, bringing together a wide range of researchers to share their findings.
Professional Development (CPD)
This event is approved by the Royal Society of Biology for purposes of CPD
and may be counted as 54 CPD credits