Branch AGM and talk on Making Sense of the Metabolic Milieu: Methods for Characterising the Human Exposome by Dr Toby Athersuch
The meeting will include reports by the branch chair and treasurer, the election of committee members, any other business raised by branch members and a talk on Making Sense of the Metabolic Milieu: Methods for Characterising the Human Exposome by Dr Toby Athersuch from Imperial College London.
The phenomenal interest and investment in identifying genetic determinants of chronic diseases, coupled with the increasing speed and decreasing cost of sequencing technologies, has powered the genomics-based revolution in personalised healthcare and molecular epidemiology. Despite these advances, only a fraction of total disease risk can be attributed to known genetic factors. Traditional research methods into non-genetic (i.e. environmental) factors that may contribute to adverse health outcomes have been limited to the study of a relatively small selection of key chemicals, with exposures often being considered in isolation from the complex mixtures in which they may be typically encountered.
The concept of a human exposome - a counterpart to the human genome - has been developed over recent years to address these limitations and explore gene-environment interactions in a more holistic manner. It forms the basis for large-scale epidemiological studies aimed at identifying the environmental determinants of chronic disease; integrating individual measures of the internal and external chemical environment, along with genome data promises to yield new biological insight. The human metabolome is a major part of the biochemical interface between an organism and its environment, and the complement of small molecule metabolites in the body represent an important integrator between the internal chemical milieu and the external environment. Characterising the human metabolome is therefore critical to the conduct of effective exposome studies.
In this whistle-stop tour, Dr Athersuch will cover some of the basic aspects of how the metabolome can be measured, what these measurements can tell us, and how these can be integrated with other data in exposome studies to reveal new insight about human health and disease. Further details about the talk is available to download.
The agenda for the AGM is available to download
, and branch members that would like to submit any other business can do so by getting in touch with Dr Ralph Manly at email@example.com
Cost and booking
The event is free to attend and open to all, although only members can vote on any agenda items. Advance booking is essential using the link at the top of the page. The Zoom meeting joining link will be circulated to registered guests ahead of the event.
Please direct all event enquiries to Dr Ralph Manly at firstname.lastname@example.org
For general RSB enquiries, please contact Beth Morgan at email@example.com