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Oxford RSB Primers

PROTACs in Drug Discovery

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Date
04.07.22
Where
Francis Crick Institute, London

A training workshop from the British Pharmacological Society


This training workshop will introduce and explore the role of proteolysis targeting chimeras (PROTACs) as bifunctional molecule protein degraders. This will include their application in drug discovery and why they offer a new approach in targeting some diseases over conventional small molecule drugs.

The workshop is part of the New Modalities in pHarmacology and Drug Discovery joint meeting from the British Pharmacological Society and ELRIG UK.

This training is aimed at early career researchers, pre-clinical and clinical scientists/professional wanting to learn more about these new drug modalities within drug discovery.

Join for an introductory level expert led series of discussions and small group problem-based learning sessions on:
  1. The biophysics of PROTACs and understanding the cooperativity of PROTAC molecules.
  2. The function of turning a protein binder into a protein degrader. Including PROTAC selectivity and SAR.
  3. An understanding of the safety of PROTACs and how this can be profiled and optimised for development.
  4. The current developments in PROTAC design and new ligases for the future.

Continuing Professional Development (CPD)

This event is approved by the Royal Society of Biology for purposes of CPD and can be counted as 24 CPD points.

Further details

Visit the BPS website for additional information and to register.